Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation
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Quasi-native chaperonin-bound intermediates in facilitated protein folding.
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15 صفحه اولCharacterizing protein folding intermediates.
To determine the pathway by which a protein folds up, it is necessary to characterize the structures of folding intermediates and also to place these intermediates in the correct order on the kinetic pathway of folding. Noncovalent folding reactions are fast: typically they occur in seconds or less for small single-domain proteins. On the other hand, hours are required to obtain detailed struct...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1997
ISSN: 1460-2075
DOI: 10.1093/emboj/16.2.221